The role of mitochondrial dysfunction in cellular senescence and Alzheimer’s disease-related amyloid pathology
Nuria Suelves Caballol, Tasha Ibrahim, Shirine Saleki, Debora Palomares, Pascal Kienlen-Campard · FENS Forum 2024
Aging is the main risk factor for Alzheimer’s disease (AD), a prevalent and devastating neurodegenerative pathology with no effective cure. Research efforts aimed at understanding the link between pathological aging (senescence) and AD are crucial for developing pharmacological therapeutic strategies. Mitochondrial dysfunction and mitophagy defects are observed during senescence and AD, and studies suggest that they might lead to Aβ accumulation. Our goal in this project was to explore if a reduced removal of dysfunctional mitochondria during aging is a key contributor to amyloid pathology and
ePoster · Neuroscience