Topic: TercKO

Neurodegenerative diseases are the most prevalent age-related pathologies, including Alzheimer’s disease (AD). Recent studies suggest that telomere attrition, the main trigger of cellular senescence and pathological ageing may contribute to brain dysfunction and neurodegeneration. Senescent brain cells have been observed in AD brains, and studies in a transgenic mouse model of tauopathy found that the elimination of senescent cells led to an improvement in neurodegeneration and cognitive decline. In this project, we aim to unravel the relationship between brain senescence and the onset and pro