Topic: Tet2

Adult neurogenesis in the mammalian brain is mainly supported by neural stem cells (NSCs) located in the subventricular zone (SVZ) of the lateral ventricles. This process is regulated by specific extracellular and intracellular factors such as genomic imprinting (GI). GI is an epigenetic process that causes the monoallelic expression of a certain genes, called imprinted genes, being these expressed according to their parental origin. This phenomenon is controlled by epigenetic modifications at the imprinting control regions (ICR) that are differentially DNA methylated regions (DMRs) on the two