The impact of clonal hematopoiesis on neuroinflammation after ischemic stroke in a chimeric bone marrow mouse model
Polina Bugaeva, Paul Fischer, Amelie Weber, Daniel Berchtold, Stefan Jordan, Leif Koschützke, Christian Hoffmann, Matthias Endres, Anna Malik, Steffen Jung, Daniel Lewandowski, Christoph Harms · FENS Forum 2024
Clonal hematopoiesis, which refers to somatic mutations in hematopoietic stem cells (HSC), is recognized as a risk factor for stroke. Tet2 mutations exerted the greatest influence on complex cardiovascular endpoints in a study of incident strokes. The aim of this preclinical study was to explore if mutant HSC exhibit an aggressive phenotype, releasing pro-inflammatory cytokines and causing more damage to the penumbra area, heart, endothelial cells, and the blood-brain barrier (BBB). One-leg irradiated mice grafted into with WT or Tet2-/- (induced knockout) chimeric bone marrow were subjected t
ePoster · Neuroscience