Topic: TetTag system

Memories are believed to be stored in the strengthened synaptic connectivity between distributed networks of neurons after learning. This biophysical memory trace is often referred to as an engram, provisionally defined as the cells activated during learning, reactivated during memory retrieval, and causally linked to the expression of memory. Recent work exploring the activity of these ensembles in vivo demonstrates that after learning, c-Fos tagged populations consist of highly active, correlated ensembles of hippocampal neurons. The current model for engram formation predicts that during le