Topic: TetTag transgenic mouse model

Elucidating the factors that facilitate or impede the extinction of remote memories is imperative for the advancement of targeted therapeutic interventions aimed at addressing maladaptive memory persistence. Despite the extensive body of research on memory processes, there is a notable paucity of studies focusing on the diminution of long-standing memory traces . Recently, our lab has identified a hippocampal remote recall engram that is a key player in remote memory attenuation (Khalaf et al., 2018, Science), yet its molecular underpinnings remain elusive. In this study, we seek to delineate