BDNF rescues absence seizures and their comorbid memory deficits
Tatiana Morais, Mariana Neuparth-Sottomayor, Carolina Pina, Ana M Sebastião, Giuseppe Di Giovanni, Sandra H Vaz, Vincenzo Crunelli · FENS Forum 2024
Absence seizures (ASs) are generalized non-convulsive seizures characterized by sudden, brief lapses in consciousness, accompanied by spike-and-wave discharges in EEG. In children with Childhood Absence Epilepsy, 30% are pharmaco-resistant and 60% exhibit neuropsychiatric deficits, that precede the epilepsy diagnosis and persist even after seizure control with medication. Thus, there is the need to fully understand and control both ASs and their comorbidities.Increased thalamic GABA levels have been observed in children with unilateral spike-and-wave discharges and drugs that elevate GABA can
ePoster · Neuroscience