Dissection of inter-area interactions of motor circuits
Enida Gjoni, Ram Dyuthi Sristi, Haixin Liu, Shahar Dror, Xinlei Lin, Keelin O'Neil, Oscar Arroyo, Sun Woo Hong, Sonja Blumenstock, Byung-kook Lim, Gal Mishne, Takaki Komiyama · COSYNE 2023
Motor behaviors arise from dynamic interactions of interconnected neural populations across distributed brain areas. The underlying principles of information flow remain largely unknown. Here, we investigate the functional roles of motor cortex and intralaminar thalamus in driving specific subpopulations of the striatum - the input nucleus of the basal ganglia - during movements. We recorded the activity of direct and indirect pathway medium spiny neurons (dMSNs and iMSNs) in the striatum as mice performed a skilled motor task, by in vivo two-photon calcium imaging through gradient refractive
Sun, Mar 12, 2023