The subthalamic nucleus controls nociceptive integration in the spinal cord and reverses nociceptive hypersensitivity in Parkinson’s disease
Rabia Bouali-Benazzouz, Elba Molpeceres Sierra, Houyam Tibar, Keri-Ann Charles, Khalid Oudaha, Frédéric Naudet, Pascal Fossat, Abdelhamid Benazzouz · FENS Forum 2024
Pain is one of the non-motor symptoms affecting quality of life in Parkinsonian patients. More than 80% of patients suffer from pathological nociceptive hypersensitivity, which may be due to changes in the processing of somatosensory information in basal ganglia, including the subthalamic nucleus (STN). However, the underlying mechanisms are not yet defined.The aim of this study was i) to characterize the responses of STN neurons to peripheral nociceptive stimulation under normal and pathological conditions and ii) to investigate the effects of deep brain stimulation (DBS) of the STN on nocice
ePoster · Neuroscience