Thermosensory atypia in newborns mutant for an autism-related gene MAGEL2
Ugo Zayan, Dmitrii Suchkov, Anastasia Ludwig, Stefania Sarno, Francoise Muscatelli, Claudio Rivera, Valéry Matarazzo · FENS Forum 2024
Atypical responses to sensory stimuli are considered a core aspect and early life marker of Autism Spectrum Disorders (ASD). Although recent findings performed in mouse ASD genetic models report sensory deficits, these were explored exclusively during the juvenile or adult period. Our research concentrates on neonate mice lacking the autism-associated gene Magel2. MAGEL2 is an imprinted gene highly expressed in the hypothalamus that is paternally expressed and for which paternal deletion and point mutation cause Prader-Willi and Schaaf-Yang respectively; two syndromes with a high prevalence of
ePoster · Neuroscience