Topic: Theta and Gamma rhythms

The amyloid-β precursor protein (APP) is a transmembrane protein constitutively expressed in the brain and highly implicated in Alzheimer’s disease aetiology. We previously identified a novel cleavage site of APP, the η-secretase site (Willem et al. Nature 2015, PMID:26322584). Peptides resulting from this cleavage and α- or β-secretase-dependent proteolysis are the extracellular soluble AETA peptides (Aη-α or Aη-β, respectively). Our previous work also demonstrated that AETA modulates synaptic plasticity and significantly reduces calcium activity in the hippocampus (HPC) in vivo. These result