Effects of early life stress on mouse sleep architecture and spindle activity
Mohsin Mohammed, Malvika Sharma, Janine Micahella Contreras, Dipesh Chaudhury · FENS Forum 2024
Early life stress (ELS) significantly impacts neurodevelopment and behavior. Recent studies suggest a strong link between ELS and poor sleep quality. Poor sleep correlates with increased risk of psychiatric disorders such as anxiety and vulnerability to stress. In this study, we investigated ELS effects on sleep architecture and spindle activity in mice. Two groups were used: ELS group experienced maternal separation for 3 hours daily from postnatal day 1-14, and a stress-naive control group. At the 8 weeks age, EEG and EMG electrodes were implanted for sleep recording. While wake and NREM sle
ePoster · Neuroscience