Sleep architecture in C57BL/6 mice predicts anxious phenotypes: Towards a first robust animal model for postoperative delirium
Alp Altunkaya, Kim Michelle Mengel, Buket Solak, Alice Caterina Pasquini, Annabelle Bahmann, Matthias Kreuzer, Gerhard Schneider, Thomas Fenzl · FENS Forum 2024
Postoperative delirium (POD), expressed from mild forms such as short cognitive impairments to chronic cognitive deficits or death, is relevant in up to 80% of patients after surgery under general anesthesia (GA). The systemic and mechanistic relationship between preoperative anxiety (POA) and POD is largely unknown. A preoperative anxious phenotype and the identification of sleep impairments due to it hold the strong potential to establish predictive parameters for POD. These discoveries may further elucidate the neuronal mechanisms underlying POA and POD. 37 C57BL/6N male mice (12-weeks-old)
ePoster · Neuroscience