Type one diabetes modifies tau phosphorylation patterns and worsens cognitive impairment in the APP/PS1 mouse model of Alzheimer’s disease
Miriam Corraliza-Gomez, Maria Vargas-Soria, Carmen Infante-Garcia, Alan W. Stitt, Rafael Simó, Mónica García-Alloza · FENS Forum 2024
Alzheimer’s disease (AD) is the most common cause of dementia. Despite age being the main risk factor, previous studies have also reported that type 1 diabetes (T1D) may contribute to abnormal tau phosphorylation and worsen cognitive impairment in AD patients. However, the underlying mechanisms are not completely understood. Therefore, we have analyzed the effects of streptozotocin (STZ)-induced T1D in a mouse model of AD (APP/PS1) in terms of metabolic impairment, cortical tau phosphorylation and cognition at 26 weeks of age, when the pathology is fully established. When all groups under stud
ePoster · Neuroscience