Topic: three-chamber apparatus

Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterized by early-onset impairments in social communication, repetitive behaviors and stereotypies. The present study was designed to investigate the developmental alteration of social behavior in rat model of autism induced by valproic acid (VPA). Experiments were carried out on prenatally VPA-treated and control (saline treated) rats at two different ages: adolescent (postnatal day 30) and young-adult (3 months-old) male rats. Sociability was evaluated in a three-chamber apparatus. The results showed that groups of