Topic: three-dimensional neural organoids

Differentiation of human induced pluripotent stem (hiPS) cells into three-dimensional neural organoids is already enabling access to key developmental processes in the human nervous system and offers an opportunity to model severe neurological disorders. Our laboratory has pioneered the use of instructive signals to derive regionalized neural organoids. Automation for high-throughput generation of these neural organoids could facilitate drug and genetic screening applications, especially if amenable to arrayed production. Here, we develop a platform relying on inexpensive equipment for automat