The role of afferent hippocampal to prefrontal cortex projections in a mouse model of Alzheimer's disease
Emine Ciftci, Eleonora Ambrad, Manuel Mittag, Falko Fuhrmann, Stefanie Poll, Martin Fuhrmann · FENS Forum 2024
Alzheimer’s disease (AD) is characterized by memory deficits including spatial working memory. The hippocampus (HPC) and the prefrontal cortex (PFC) exhibit a prominent AD pathology and are relevant brain regions for spatial working memory. The HPC and PFC are connected by long-range projections and operate in synergy to consolidate and retrieve memories. Both, excitatory and inhibitory long-range projections between the HPC and the PFC have been poorly characterized under AD-like conditions. In fact, it remains unknown, whether structural and functional connectivity deficits between these bra
ePoster · Neuroscience