Brain-wide, specialized and state-dependent cortical encoding of reward, value and action switching during reversal learning
Murat Yildirim, Nhat Le, Yuma Osako, Yizhi Wang, Abigail Dulski, Alexandria Barlowe, Hiroki Sugihara, Peter So, Mriganka Sur · COSYNE 2023
In reversal learning tasks, large-scale circuits in multiple brain areas are involved in encoding multiple decision variables, such as trial outcomes, action values and action switching. It is unknown how spatiotemporal patterns of cortical encoding differentially encode these variables and whether the encoding depends on the level of engagement in the task. Here, we used a combination of large-scale imaging techniques and computational methods to investigate the representation of reward-related decision variables at the widefield and single-neuron levels. Widefield imaging and unsupervised an
Sun, Mar 12, 2023