Disease-associated microglia-dependent and independent pathophysiology in spinal cord lesions in amyotrophic lateral sclerosis
Kazuya Takahashi · FENS Forum 2024
Background: Amyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease of the central nervous system. Despite an unknown etiology, its pathophysiology is considered to be heterogeneous. Recent reports have highlighted the presence of disease-associated microglia (DAM) in the lesions of various neurodegenerative diseases, including that in ALS model animals. However, limited information is available regarding DAM in sporadic cases of ALS in humans.Methods: This study analyzed data from 30 patients with ALS. Autopsy samples of cervical and lumbar lesions obtained from each p
ePoster · Neuroscience