Functional and anatomical modifications of peritumoral tissue that occur along with glioma progression
Elisabetta Mori, Cristina Spalletti, Sabrin Haddad, Marta Scalera, Marco Mainardi, Daniele Cangi, Vinoshene Pillai, Elena Parmigiani, Silvia Landi, Matteo Caleo, Eleonora Vannini · FENS Forum 2024
Glioblastoma Multiforme (GBM) is the most aggressive form of brain tumors. It affects 3 in 100,000 people and has a median survival of 15 months. GBM is known to infiltrate the surrounding brain parenchyma, interacting with neuronal tissue. Specifically, tumoral cells induce neuron hyper-excitability while peritumoral cells seem to regulate tumor proliferation and progression. This project aims to investigate how the plastic rearrangement of cortical areas occurs in glioma-bearing animals. We took advantage of Thy1-ChR2 transgenic mice, injected with two syngeneic lines of murine glioma cells
ePoster · Neuroscience