Extracellular vesicles from hypothalamic astrocytes modify transcription factors of the leptin signaling pathway in proopiomelanocortin (POMC) neurons
Alfonso Gómez Romero, Roberto Collado-Pérez, María Jiménez-Hernáiz, J Argente, Julie Ann Chowen, Laura María Frago · FENS Forum 2024
The hypothalamus is the central regulator of homeostasis with proopiomelanocortin (POMC) neurons in the arcuate nucleus playing a fundamental role. These neurons release neuropeptides that promote energy expenditure and satiety and are a target for leptin, an anorexigenic hormone of adipose tissue origin. POMC neurons communicate with hypothalamic astrocytes via extracellular vesicles (EVs) that contain proteins, lipids, and nucleic acids, and relay information regarding metabolic status. Our hypothesis is that astrocytes affect neuronal function and leptin signaling pathway in a nutrition-dep
ePoster · Neuroscience