Tibolone improves locomotor function in a rat model of spinal cord injury by modulating apoptosis and autophagy
Angélica Coyoy, Stephanie Sánchez-Torres, Carlos Orozco-Barrios, Hermelinda Salgado-Ceballos, Julia J Segura-Uribe, Christian Guerra-Araiza, Ángel León-Cholula, Julio Morán · FENS Forum 2024
Spinal cord injury (SCI) results from direct damage to the spinal cord, devastating patients’ quality of life and emotional and economic stability. Unfortunately, fully effective therapeutic strategies have yet to be developed to treat this disease, affecting millions worldwide. Apoptosis and autophagy are critical cell death signaling pathways after SCI that should be targeted for early therapeutic interventions to mitigate their adverse effects and promote functional recovery. Tibolone (TIB) is a selective tissue estrogen activity regulator (STEAR) with neuroprotective properties demonstrate