Changes in mitochondrial respiration and mitochondrial dynamics induced by mitochondrial complex I inhibition in primary cortical neurons: Association with schizophrenia-like phenotype
Amanda Siena dos Santos, Luiz Felipe Souza e Silva, Vitória Cristina Araújo, Martina Raissa Ribeiro, Diana Zukas Andreotti, Larissa de Sá Lima, Ana Maria Orellana, Elisa Mitiko Kawamoto, Tatiana Rosado Rosenstock, Cristoforo Scavone · FENS Forum 2024
The goal of this work is to analyze the mitochondrial changes that Rotenone (Rot) treatment can induce in primary cortical neurons that could contribute to the schizophrenia-like phenotype animal model, previously demonstrated by our research group. For this, we previously determined the Rotenone (Rot) concentration in the cortex (1.325nM) from our animal model with a schizophrenia-like phenotype. Then, we treated the primary cortical neurons with Rot 1.325nM for 24h and investigated: the Rot cellular viability treatment by MTT and CytotoxGlo assay; CI enzymatic activity; oxygen consumption ra
ePoster · Neuroscience