Topic: time-compressed sequential representations

Studies suggest that adaptive behaviors arise from multiple decision systems in the brain, and spatial complexity affects these processes. Three regions are hypothesized to make distinct contributions: hippocampus (HC) — encoding state-space and enabling flexible behaviors, dorsolateral striatum (DLS) — encoding action-chains and enabling automated behaviors, and prefrontal cortex (mPFC) — encoding task-space and strategy-setting. We simultaneously recorded across these regions, and in a separate cohort we chemogenetically inhibited mPFC on a rule-switch task, the left/right/alternation foragi