Topic: timsTOF-HT

The brain reveals a complex architecture of > 150 distinct regions. Over the last decade tremendous efforts have been undertaken to elucidate the molecular organization of these subregions. Various consortia mapped the human brain morphology, structure, and function using imaging and RNA expression profiling. This study adds to these approaches by providing a comprehensive, quantitative protein expression map of 13 anatomically distinct brain regions covering over 11,000 proteins (Tueshaus et al., 2023)Recent technical progress in the area of liquid chromatography, mass spectrometry and dat