Anti-inflammatory effect of alpha-pinene on the neuroinflammation induced by morphine dependence and withdrawal is mediated by modulating toll-like receptor signaling pathway
Shamseddin Ahmadi, Hawsar Rashid Ahmed · FENS Forum 2024
Neuroinflammation mediated by toll-like receptors (TLRs) signaling pathway has a substantial role to morphine addiction. Αlpha-pinene is a member of the monoterpene family that has exhibited anti-inflammatory effects. This study aimed to examine the anti-inflammatory effects of alpha-pinene treatment on TLRs signaling pathway in the rat hippocampus after morphine dependence and withdrawal. Six groups of male Wistar rats were used in two categories, including dependent and withdrawal. Morphine (10 mg/kg) was intraperitoneally injected twice daily for 10 consecutive days to induce dependence. Al
ePoster · Neuroscience