Role of TLR4 pathway in the prefrontal cortex following acute and chronic administration of morphine and its withdrawal syndrome
Victoria Gómez-Murcia, Aurelio Franco, Francisco Fernandez-Gomez, Maria Victoria Milanes, Cristina Nuñez · FENS Forum 2024
Opiates addiction is a major public health problem worldwide. This condition has been conventionally considered to be a consequence of the neuronal activation of classical opioid receptors. However, nowadays numerous studies point out to the TLR4 signaling pathway as a target for opiates and its participation, through the modulation of neuroinflammatory mechanisms, in many of these drugs’ effects has been postulated. Thus, glial cells are currently the focus of a number of studies in order to understand their contribution to the addictive properties of opiates, as they have the ability to modu
ePoster · Neuroscience