Exploring the neural transcriptomic environment of TLR7-activated neuroinflammation
Kirstyn Gardner-Stephen, Rhona McGonigal, Alison McColl, Louis Nerurkar, John Cole, Nigel Jamieson, Jonathan Cavanagh · FENS Forum 2024
Neuroinflammation is associated with many medical conditions that exhibit both CNS and behavioural changes. Understanding the biological mechanisms underpinning these inflammation-triggered changes may aid therapeutic discovery and further pathophysiological involvement in several neuropsychiatric conditions (e.g. depression and anxiety). Upon activation, toll-like receptor 7 (TLR7) triggers an interferon-mediated inflammatory response. In this study, we utilise the non-invasive, TLR7-activated Aldara Imiquimod mouse model to investigate the transcriptomic changes within the pro-inflammatory n
ePoster · Neuroscience