Multi-omics approach identified a network of lipids and proteins associated with lysosomal and mitochondrial metabolism in Parkinson’s disease patients carrying mutations in TMEM175 gene
Federica Carrillo, Marco Ghirimoldi, Giorgio Fortunato, Nicole Piera Palomba, Laura Ianiro, Antonietta Di Lorenzo, Veronica De Giorgis, Sara Pietracupa, Nicola Modugno, Elettra Barberis, Marcello Manfredi, Teresa Esposito · FENS Forum 2024
In this study we investigated whether the presence of mutations in TMEM175 gene could reflect a characteristic lipidomic, metabolomic and proteomic signature of PD patients both at circulating and cellular levels.The study cohort included two groups of patients that differ for the presence of TMEM175 mutations, and a group of matched controls. We adopted an untargeted omics approach to disclose lipidomic, metabolomic and proteomic alterations in PD patients carrying TMEM175 mutations both in plasma and dermal fibroblasts.Integrated analysis of omics data revealed wide deregulation of lysosome,
ePoster · Neuroscience