Extracellular vesicles from mesenchymal stem cells alter gut microbiota and improve neuroinflammation and motor impairment in rats with mild liver damage
Gergana Mincheva, Vicente Felipo, Victoria Moreno-Manzano, Alfonso Benítez-Páez, Marta Llansola · FENS Forum 2024
Gut microbiota perturbation and motor dysfunction have been reported in steatosis patients. Rats with mild liver damage (MLD) also show motor dysfunction mediated by neuroinflammation and altered GABAergic neurotransmission in the cerebellum. The extracellular vesicles from mesenchymal stem cells (MSC-EVs) have emerged as a promising therapeutic proxy whose molecular basis rely partly upon TGFbeta action. Therefore, this study aimed to assess if MSC-EVs improve motor dysfunction in rats with MLD and analyze underlying mechanisms, including the role of EVs, TGFbeta, neuroinflammation, and gut m
ePoster · Neuroscience