Administration of a TNF receptor 2 agonist improves neuropathology and cognitive functions in an Alzheimer’s disease model
Natalia Ortí Casañ, Harald Wajant, H. Bea Kuiperij, Marcel M Verbeek, Peter P De Deyn, Petrus JW Naude, Ulrich L M Eisel · FENS Forum 2024
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Accumulating experimental evidence shows the important role of tumor necrosis factor-α (TNF-α) signaling in AD, but the exact role of TNF-α in AD is still not completely understood. Although TNF-inhibitors are successfully used for treatment of several autoimmune diseases, like rheumatoid arthritis, total inhibition of TNF-α can cause adverse side effects in neurological diseases. This is attributed to the opposing roles of the two receptors of TNF-α. TNF receptor 1 (TNFR1) predominantly
ePoster · Neuroscience