Toll-Like Receptor 4 (TLR4), a target for cytoprotection and (re)myelination in multiple sclerosis
Beatriz Fernández-Gómez, Miguel Marchena, Estefanía Sánchez, Paula Gómez-Martín, Macarena Hernández-Jimenez, David Piñeiro, Micaela Della Seta, Elissavet Kikidou, Fernando de Castro · FENS Forum 2024
Toll-Like Receptor 4 (TLR4) is a relevant actor for innate immunity involved in inflammatory responses in Multiple Sclerosis (MS) and other diseases. The currently available therapeutic arsenal to treat MS is composed of immunomodulators but, to date, there are no (re)myelinating drugs available in clinics. In the present work, we study the effect of TLR4 inhibition in different animal models of MS.The experimental autoimmune encephalomyelitis (EAE) model was used to evaluate the effect of TLR4 inhibition on reducing the inflammatory component. A more direct effect on oligodendroglia was studi
ePoster · Neuroscience