Recombinant versus patient-derived soluble tau: Distinct effects of tau antibodies on disruption of synaptic plasticity in vivo
Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Michael Rowan · FENS Forum 2024
The interaction of amyloid-beta and microtubule-associated protein tau, the two hallmark proteins of Alzheimer’s disease (AD) age-related pathology, that cause disruption of synaptic long-term potentiation and depression (LTP and LTD, respectively) is still poorly understood. Here, we recorded field excitatory postsynaptic potentials from the CA1 stratum radiatum in young and middle-aged rats under urethane anesthesia to examine the disruptive action of synaptotoxic tau in recombinant protein preparations or aqueous brain extracts from patients with AD and Pick’s disease (PiD) tauopathy. A sin
ePoster · Neuroscience