Topic: tonic extracellular concentration

Dopamine (DA) release in the striatum regulates reward, motivation, and locomotion. The release is considered to have a short-lived phasic and continuous tonic component. Recent studies, however, have challenged the existence of tonic DA and revealed major regional diversity in extracellular DA dynamics. Here we build a large-scale three-dimensional model of extracellular DA dynamics in the dorsal (DS) and ventral striatum (VS) based on experimentally determined biological parameters. The model predicts rapid dynamics in DS with little-to-no basal DA, whereas the lower uptake capacity in VS sl