Topic: topological associated domains

The mammalian genome is folded into complex structures giving rise to multiple layers of compaction, while still accommodating dynamic and complicated tasks such as replication, transcription, and DNA repair. It is now widely accepted that the 3-dimensional (3D) genome organization plays an important role in both establishing and maintaining stable gene expression patterns, which impacts the development of cell-type identities. The development of chromosome conformation capture (3C) technology has been crucial in the endeavor to understand the organization of the 3D genome, and various structu