Neural bursts and firing regularity as convergent neural dynamics in globus pallidus for genetic dystonia syndromes
Ahmet Kaymak, Fabiana Colucci, Mahboubeh Ahmadipour, Hagai Bergman, David Arkadir, Zvi Israel, Nico Golfrè Andreasi, Roberta Telese, Sara Rinaldo, Vincenzo Levi, Giovanna Zorzi, Jacopo Carpaneto, Miryam Carecchio, Holger Prokisch, Michael Zech, Barbara Garavaglia, Roberto Eleopra, Alberto Mazzoni, Luigi Michele Romito · FENS Forum 2024
Genetic dystonia is a complex movement disorder with diverse clinical manifestations arising from pathogenic mutations in various genes. The growing body of research indicates shared pathomechanism among these genes, yet the neural dynamics facilitating this convergence are largely unexplored. We analyzed neural patterns within globus pallidus to identify shared neural dynamics underlying functional convergence across dystonia genes. We identified 1714 pallidal neurons, isolated from explorative microelectrode recordings collected during deep brain stimulation surgery, across 32 dystonic patie
ePoster · Neuroscience