Topic: TOR1AΔGAG

DYT1 is an autosomal dominant form of dystonia, linked to a deletion (ΔGAG) in the TOR1A gene. The basal ganglia have been found to play a crucial role in the development of dystonia in the TOR1AΔGAG murine model. Experimental evidence has also indicated that the cerebellar cortex is likely to play a pivotal role in the pathophysiology of this disorder. We investigated cerebellar cortex activity and synaptic plasticity by performing extracellular recordings in acute parasagittal cerebellar slices with a high-density multielectrode array (HD-MEA) that allows to simultaneously record the activit