Topic: TORO cells

Sharp wave-ripples (SPW-Rs) are short, high-frequency electrographic events critically involved in learning and memory. In the hippocampus, where SPW-Rs are generated, distinct types of interneurons show diverse activity dynamics during these oscillations. One characteristic behaviour is displayed by TORO cells we recently described, such GABAergic neurons that show particularly robust spiking activity during SPW-Rs but reduced firing during theta activity. The disinhibitory nature of TORO cells raises the question of whether interneurons with opposite behavior also exists. In this study, us