Tottering mice display irregular firing of Purkinje neurons and impaired motor performance
Filip de Souza Polli, Kate Pedersen, Camilla T. Hjort, Kasper Larsen, Christian S. Pedersen, Benjamin J. Hall, Hanna Lindgren, Kjartan F. Herrik, Charlotte Hougaard · FENS Forum 2024
The tottering mouse, which harbors a mutation in the CACNA1A gene encoding a P/Q-type voltage-gated calcium channel, serves as a robust tool in neuroscience research for investigating Epilepsy and Episodic Ataxia Type 2 (EA2). In this study, we characterized the tottering mouse phenotype by leveraging ex vivo (loose-cell) and in vivo (extracellular) electrophysiology recordings of Purkinje cells (PCs) within the cerebellum, along with behavioral tests. Our findings reveal that tottering mice display increased irregularity in action potential (AP) firing of PCs without a change in frequency, bu
ePoster · Neuroscience