Topic: touchscreen paradigm

The self-ordered spatial search (SOSS) task is a touchscreen paradigm probing visuospatial working memory (SWM), that can be applied in non-human primate research in a preclinical translational setting. We examined the performance of the animals in the task on control baseline days and after a transient cognitive impairment induced by scopolamine, a muscarinic acetylcholine-receptor antagonist.Fourteen adult male rhesus monkeys performed the SOSS task daily, in 1-hour sessions with 300-500 trials each. In every trial the animals were shown a set of 4-8 identical cyan squares on a touchscreen,