Topic: toxic SCA8 RNA foci

We have identified a DEAD box RNA helicase and christened it as maheshvara after the powerful Hindu God Lord Shiva. Maheshvara is a novel modulator of important signaling pathways like Notch and JAK/STAT. This novel gene has an orthologue of human DDX59. Our study parallels our identification of DDX59 mutations in the human orthologue of maheshvara which causes neurological defects in humans. Our observations suggests the role of maheshvara (mahe) in modulating cellular signaling, neuronal development and disease.In addition, We have also identified novel RNA binding proteins (RBPs) which supp