Impairments in hippocampal neuronal circuit and spatial representation in 5xFAD mice performing a continuous spatial alternation task
Yimei Li, Mary Ann Go, Simon R Schultz · FENS Forum 2024
Alzheimer's disease (AD) is a complex and multi-factorial disorder, leading to progressive cognitive impairment. Hippocampal dysfunction plays a crucial role in spatial memory deficits in AD. However, the precise alterations in hippocampal neuronal activity in AD during memory-guided behaviour remain unclear. To study this, we introduced a novel behavioural paradigm for assessing spatial memory in head-fixed mice during a continuous alternation task, which can be used in conjunction with two-photon calcium imaging to investigate changes in hippocampal network activity, including spatial and tr
ePoster · Neuroscience