Phase-locked transcranial intersectional short pulse (ISP) stimulation in terminating epileptic seizures
Nóra Kata Forgó, Lívia Barcsai, Márton Görög, Dániel Fabó, Loránd G. Erőss, Orrin Devinsky, Zoltán Chadaide, Antal Berényi · FENS Forum 2024
Transcranial Electric Stimulation (TES) has emerged as a promising non- or minimally-invasive therapeutic approach for drug resistant epilepsy treatment. However, the optimaltiming of stimulation relative to the ongoing brain oscillations remains to be established foroptimizing efficiency.This study investigates the phase specificity of transcranial ISP stimulation in terminatingepileptic seizures, using both animal models and clinical data. By analyzing deep-brainactivity during seizures in rats and post-hoc analysis of clinical data from human patientsunderwent closed-loop ictal stimulation,
ePoster · Neuroscience