Role of NCOR1 and NCOR2 transcriptional corepressors in myelin development and remyelination
Rubí Hernández Rojas, Ángeles Casillas-Bajo, Alerie Guzman de la Fuente, Jose A. Gómez-Sáchez, Hugo Cabedo · FENS Forum 2024
The transcriptional corepressors NCOR1 and NCOR2 are part of a multiprotein complex that downregulates Jun and triggers the transcription of myelin genes in cultured Schwann cells (SC) (Gomis-Coloma et al., 2018). Both corepressors are also expressed in oligodendrocyte lineage cells, both oligodendrocytes (OL), and in OL precursor cells (OPCs), suggesting that they might contribute to their development and function (Castelo-Branco et al., 2014). Using genetically modified mice we have previously shown that they are dispensable for myelin development in the peripheral nervous system (PNS). In t
ePoster · Neuroscience