Topic: transcriptional dynamics

Cell identity and states are dictated by gene expression programs, influenced by a range of epigenetic modalities. In the neuronal system, these mechanisms underlie various functions, such as maturation and memory formation, and their deficits are linked to various neurological disorders. Recent advancement of single-cell sequencing technologies, including scRNA-seq, has accelerated our understanding of the cellular diversity with respect to molecular profiles. However, existing high-throughput sequencing methods have an inherent limitation that they can primarily provide a static ‘snapshot’ o