Combined electrophysiologic and transcriptomic characterization reveals different functional populations of GABAergic spinal neurons in neuropathic pain mouse model
Charline Kambrun, Florian Specque, Vanessa Rouglan, Alexis Groppi, Macha Nikolski, Alexandre Favereaux, Yves Le Feuvre · FENS Forum 2024
Pain elaboration results from the integration within dorsal spinal cord networks of sensory and nociceptive information conveyed by primary afferents. While many evidence suggest that a major disinhibition of dorsal horn networks may promote enhanced pain transmission in chronic pain pathologies, little is known about inhibitory neurons properties themselves and whether specific inhibitory subpopulations are preferentially altered in chronic pain conditions.We used the Spared Nerve Injury (SNI) neuropathic pain model on Gad67-GFP transgenic mice, which specifically labels dorsal horn inhibitor
ePoster · Neuroscience