Topic: transient cerebral ischemia

In this study, we explored the neuroprotective properties of a novel Tat-CRYM recombinant protein, designed with a Tat domain to enhance blood-brain barrier permeability, within a transient cerebral ischemia using Mongolian gerbils. Our focus was on Ketimine reductase mu-crystallin (CRYM), a protein with widespread distribution in the brain, including areas like the cerebral cortex, corticospinal tract, and basal ganglia, and its diminished expression in neurodegenerative diseases such as Huntington's and Alzheimer's.We assessed the intracellular uptake of Tat-CRYM protein by NSC34 cells, reve