HIF-1α induces CaV3.2 and paves the way for post-ischemic epileptogenesis
Anna Tröscher, Despina Tsortouktzidis, Tim J. von Örtzen, Helbok Raimund, Albert J. Becker, Karen M.J. van Loo · FENS Forum 2024
Stroke is one of the main reasons of acquired epilepsy in adults. Little is known about the underlying pathomechanisms that occur during epileptogenesis, so between the transient hypoxia and the first late seizure.Some transcription factors drive gene-expression towards an epileptogenic phenotype through channelopathies, which may be acquired through brain insults, such as the T-type Ca2+ channel CaV3.2.Hypoxia-inducible factor 1α (HIF-1α) is quickly activated and can bind to the promoter of CaV3.2, potentially inducing an epileptogenic cascade in penumbra neurons.We used NS20Y cells and prima
ePoster · Neuroscience