Topic: Transient receptor potential ankyrin 1

Transient receptor potential ankyrin 1 (TRPA1) plays a pivotal role in migraine pathogenesis via regulating cortical spreading depression, neuroinflammation, hyperalgesia and trigeminovascular system activation and sensitization. However, whether TRPA1 could affect photophobia, a symptom that affects ~80% migraineurs, is unknown. In this study, we examined whether TRPA1 activation triggers photophobia, and displays a gender-specific difference in photophobia behavior. C57BL/6J mice were used to assess mouse behavior in both dark and light compartments of a chamber. The photophobia behavior was