Astrocytes provide the temporal dynamic required for theta-driven memory formation in the hippocampus
Silas Larsen, Nikolaj Winther Hansen, Navneet A Vasistha, Konstantin Khodosevich, Jean-Francois Perrier · FENS Forum 2024
Theta oscillations (4-12 Hz) in the hippocampus are caused by the synchronous bursting activity of neuronal populations. They are critical for grouping and selecting neuronal ensembles in the context of spatial navigation, memory, and learning, but the reason why this frequency band is particularly effective for adjusting neuronal ensembles remains speculative. Here we show that burst activity at the CA3-CA1 synapse of the mouse hippocampus leads to a rapid activation of astrocytic leaflets possibly via the retrograde release of endocannabinoids that activate transient receptor potential chann
ePoster · Neuroscience